First step in developing a 3D biodegradable fibrin scaffold for an artificial ovary
نویسندگان
چکیده
منابع مشابه
First step in developing a 3D biodegradable fibrin scaffold for an artificial ovary
BACKGROUND Although transplantation of cryopreserved ovarian tissue is a promising approach to restore fertility in cancer patients, it is not advisable for women at risk of ovarian involvement due to the threat of reintroducing malignant cells. The aim of this study was therefore to find an alternative for these patients by development of an artificial ovary. METHODS For construction of the ...
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Due to the increasing needs for organ transplantation and a universal shortage of donated tissues, tissue engineering emerges as a useful approach to engineer functional tissues. Although different synthetic materials have been used to fabricate tissue engineering scaffolds, they have many limitations such as the biocompatibility concerns, the inability to support cell attachment, and undesirab...
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For women diagnosed with leukemia, transplantation of cryopreserved ovarian tissue after disease remission is not advisable. Therefore, to restore fertility in these patients, we aim to develop a biodegradable artificial ovary that offers an environment where isolated follicles and ovarian cells (OCs) can survive and grow. Four NMRI mice were ovariectomized and their ovaries used to isolate OCs...
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ژورنال
عنوان ژورنال: Journal of Ovarian Research
سال: 2013
ISSN: 1757-2215
DOI: 10.1186/1757-2215-6-83